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KMID : 0941820120220030228
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Korean Journal of Clinical Pharmacy
2012 Volume.22 No. 3 p.228 ~ p.233
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Aspect of Blood Pressure after Oral Administration of Alcohol : Effect of Dissolved Oxygen on Blood Pressure
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Song Byung-Jeong
Lee Byung-Yo
Chae Jung-Woo
An Jung-Hwa
Kwon Kwang-Il
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Abstract
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Purpose: The purpose of this study was to elucidate the effect of dissolved oxygen in alcohol to blood pressure of healthy persons.
Methods: Subjects (n=30) were randomized in a double blind crossover study to receive 120 mL, 240 mL, 360 mL of alcohol (Korean spirit, 19.59 v/v%, dissolved oxygen is 8 ppm and 20 ppm). Blood alcohol concentration (BAC) and blood pressure were measured applying Lion SD-400 Alcolmeter® Breathalyser and Tensoval duo control. Pharmacokinetic parameters (Cmax, Tmax, AUClast, Kel, Vd, Clearance) were calculated using Winnonlin ® program. The difference of parameters and values were analysed by student t-test using Microsoft® Excel program.
Results: The AUClast values of 8 ppm group and 20 ppm group in 240 ml administration were 6.15±2.60 cg·min/ml, 5.33± 1.84 cg·min/ ml (p<0.05) and those in 360 mL were 11.93±5.70 cg·min/ml, 10.33±4.60 cg·min/ml (p < 0.01), respectively. Thus, the AUClast was significantly decreased. On the other hands, there was a significant change in systolic blood pressure (SBP) after alcohol administration. All measured value after 360 mL of alcohol administration was significantly decreased (p < 0.01).
Conclusions: The dissolved oxygen in alcoholic beverage has no effect on blood pressures but the alcohol administration has an effect on blood pressure. Thus, SBP can be used as a biomarker of alcohol administration and utilized in PK/PD modeling of alcohol.
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KEYWORD
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alcohol, pharmacodynamic, blood pressure, dissolved oxygen
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